Staying Alive: A Cell’s Perspective

I am a cell. My glucose uptake is impaired. If I can’t take up glucose, that could be disastrous, in terms of survival. Fortunately, I have another option. I can make my own energy. I can ferment energy. I can run the energy equation (Krebs cycle) in reverse.

What might impair the uptake of glucose (and insulin)? Scale. The relative size of the molecules. The molecules have to fit.

For that matter, if I am not to scale, how can I utilize fats?

If I cannot make new lipid membranes—recall that every cell is surrounded by a phospholipid bilayer, where food can enter and waste can exit—I become trapped. If I can’t make new lipid membranes, then I cannot make new cells, and I cannot fix the issue of my scale being off.

So here I am, I am running Krebs in reverse, fermenting energy. I am so small (or so large) that I am “locked out” of my own glucose and insulin. And I can’t use my fats to make new cells and thus fix the scale issue.

Sound familiar?

This book, about a controversial physician named Emanuel Revici, is not well-written. It plays coy with information, which I dislike (I do not read mysteries).

I made myself keep reading to the end anyway. The central pillar of Revici’s approach to cancer? Fats. Provide fats. Long-chain? Short-chain? I couldn’t tell you; it was not made clear. But I found that little nugget of information interesting. https://www.amazon.com/Doctor-Who-Cures-Cancer/dp/1438263902

Might scale play a role in human disease?

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