Staying Alive: A Cell’s Perspective

I am a cell. My glucose uptake is impaired. If I can’t take up glucose, that could be disastrous, in terms of survival. Fortunately, I have another option.

I can make my own energy. I can ferment energy. I can run the energy equation (Krebs cycle) in reverse.

What might impair the uptake of glucose (and insulin)? Scale. The relative size of the molecules.

For that matter, if I am not “to scale,” how can I utilize fats?

If I cannot make new lipid membranes—recall that every cell is surrounded by a phospholipid bilayer, where food can enter and waste can exit—I become trapped in time. If I can’t make new lipid membranes, then I cannot make new cells, and I cannot fix the issue of my scale being off.

So I am running Krebs in reverse, fermenting energy. I am so small (or so large) that I am “locked out” of my own glucose and insulin. And I can’t use my fats to make new cells and thus fix the scale issue.

Sound familiar?

This book, about a controversial physician named Emanuel Revici, is not well-written. It plays coy with information, which I dislike (I do not read mysteries).

I made myself keep reading to the end anyway. The central pillar of Revici’s approach to cancer? Fats. Provide fats. Long-chain? Short-chain? I couldn’t tell you; it was not clear to me. But I found that little nugget of information interesting.

Might scale play a role in human disease?

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