Posted on

Tryptophan: A Case Study

Here’s an example of what I believe we need to fix in our current medical paradigm.

I noticed my mother responded extremely well to tryptophan, which positively affected both her memory and her mood, so I googled “Alzheimer’s tryptophan.” The top hit was an article in the journal of the Alzheimer’s Association, by Donald F. Weaver et al, whose title declared in full caps: ALZHEIMER’S DISEASE IS A DISORDER OF TRYPTOPHAN METABOLISM.

But does the article suggest supplementing tryptophan (available for $20 on Amazon) in the treatment of Alzheimer’s? No. It wants, instead, to invent a drug that mimics tryptophan. There’s an enzyme called IDO involved in tryptophan metabolism, and this research “targets synthetic analogues of tryptophan as potential competitive inhibitors of IDO.” As a culture, as scientists, we are looking at synthetic analogues (drugs) that mimic tryptophan, rather than looking at tryptophan itself.

To be fair to ourselves and to Donald F. Weaver (who sounds like a genius who has been toiling in the Alzheimer’s trenches for years), there may be a problem with tryptophan itself. After all, it’s an amino acid found abundantly in bananas, chick peas, and turkey—among other things—so my mother is already getting it in her diet. Either her tryptophan needs are larger than her intake, or she’s not using what she gets properly, or both.

I know from my own illness journey that stress and inflammation can cause the loss of tryptophan via something known as the “Tryptophan Steal,” where tryptophan is shunted toward B3 synthesis. Loss of tryptophan to this other pathway—which can also produce a potent neurotoxin known as quinolinic acid—may be involved in the pathogenesis of Alzheimer’s. But I think there’s more to it than that. I don’t think it’s merely that her tryptophan is being lost; I think it’s that her tryptophan needs are exaggerated.

Maybe my mother’s tryptophan supply is being diminished by using her tryptophan to make DMT. (This might also explain why I recently saw a patent application to use LSD, another potent hallucinogenic that mimics DMT, as a treatment for Alzheimer’s.) If her pineal gland has located her in the past—meaning it is reading the density of the universe as higher than it actually is—and our DMT needs increase as we enter the future, then she would actually need far more DMT than her brain (her hardware) thinks she needs. Perhaps tryptophan is being used to fill that gap.

But it’s a dysfunctional loop. She needs more DMT because she’s reading time wrong. The answer isn’t to supply more tryptophan—and, consequently, more quinolinic acid—but to fix her body’s perception of time.